Local modulation of the Wnt/β‐catenin and bone morphogenic protein (BMP) pathways recapitulates rib defects analogous to cerebro‐costo‐mandibular syndrome
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چکیده
منابع مشابه
Differential effects of inhibition of bone morphogenic protein (BMP) signalling on T-cell activation and differentiation.
Bone morphogenetic proteins (BMPs) are involved in patterning and cellular fate in various organs including the thymus. However, the redundancy of BMPs and their receptors have made it difficult to analyse their physiological roles. Here, we investigated the role of BMP signalling in peripheral CD4(+) T cells by analysing the effects of an inhibitor of BMP signalling, dorsomorphin. Dorsomorphi...
متن کاملThe Anti-Fibrotic Effect of Bone Morphogenic Protein-7(BMP-7) on Liver Fibrosis
Background/Aims : Transforming growth factor-β1 (TGF-β1) plays an important role in the pathogenesis of liver fibrosis and cirrhosis. Recombinant human bone morphogenic protein-7 (rhBMP-7) alleviates renal fibrosis and improves kidney function. However, the beneficial effect of BMP-7 on hepatic fibrosis and cirrhosis remains unknown. The purpose of this study was to investigate the prophylactic...
متن کاملAvailable Findings Fail to Provide Strong Evidence of the Role of Bone Morphogenic Protein-2 in Femoral Head Osteonecrosis
Despite widespread research on non-traumatic femoral head osteonecrosis (FHON), there is no consensus about preventative treatment options. Insufficient blood supply and increased intra-osseous pressure are the initiating events in the majority of cases. BMPs are growth factors that belong to the transforming growth factor β (TGFβ) superfamily. Two specific formulations of BMPs have already bee...
متن کاملan investigation of the simultaneous effects of bone morphogenic protein (bmp)-4 and static magnetic field on viability and proliferation rates of rat bone marrow stem cells
objectives: this study investigated the possible synergistic effect of simultaneous treatment of bone morphogenic protein (bmp)-4 as a chemical stimulator and static magnetic field (smf) as a physical stimulator on viability percent and proliferation rate in rat bone marrow stem cells. methods: passage 5 cells were trypsinized, and a cell suspension prepared after which the cells were counted ...
متن کاملCiliary abnormalities due to defects in the retrograde transport protein DYNC2H1 in short-rib polydactyly syndrome.
The short-rib polydactyly (SRP) syndromes are a heterogeneous group of perinatal lethal skeletal disorders with polydactyly and multisystem organ abnormalities. Homozygosity by descent mapping in a consanguineous SRP family identified a genomic region that contained DYNC2H1, a cytoplasmic dynein involved in retrograde transport in the cilium. Affected individuals in the family were homozygous f...
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ژورنال
عنوان ژورنال: Journal of Anatomy
سال: 2019
ISSN: 0021-8782,1469-7580
DOI: 10.1111/joa.13144